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At first thought, it would appear that Cherie, 50, from Chicago, Illinois, and Leanne, 62, from White Plains, New York, don’t have much in common. Cherie enjoys exploring the outdoors and traveling with her husband, while Leanne, a financial advisor, enjoys making jewelry, cooking and gardening at home.
However, there is a ribbon that binds them — and it’s a teal one.
The color teal represents ovarian cancer awareness. Ovarian cancer affects a diverse group of women, and sharing their stories, such as Cherie’s and Leanne’s, uncovers that even though each and every experience is unique, women can take similar steps to find a path forward.
What you need to know about ovarian cancer
Approximately 22,000 U.S. women are projected to be diagnosed with ovarian cancer annually1 and there are an estimated 235,000 women living with ovarian cancer — many of whom will be diagnosed with advanced disease.2 For these women, the likelihood that their cancer will recur after initial treatment increases.
The possibility of recurrence can be scary and it can leave women feeling uncertain about what to do next. Fortunately, options exist for women that may help delay the cancer from coming back.3 These treatments are known as maintenance therapies.
Their path to diagnosis
With her experience in hotel management, Cherie knew she needed to utilize her communication skills to start an open dialogue with her physician so she could be as equipped as possible for the road ahead. Already attending yearly follow ups due to a personal history of breast cancer, she decided to complete genetic testing. She learned that she was positive for the BRCA gene mutation. BRCA stands for BReast CAncer susceptibility gene and can be inherited from a parent. What some people may not know is that women who are BRCA positive have a higher risk for breast and ovarian cancer.4 Testing for the BRCA gene mutation can happen prior to or after a diagnosis of ovarian cancer and is done via a blood or saliva sample.
When Cherie began experiencing abdominal pain and discomfort, she was sent for gynecological scans and referred to a gynecologic oncologist. After further examination, Cherie was diagnosed with ovarian cancer. The results from the surgery she underwent after her diagnosis indicated that she had advanced disease.
As a busy financial advisor, there wasn’t much that could slow Leanne down, until she started to experience lower abdominal pain that grew in severity. Her heart sank when she first heard the news from her OB-GYN. A tumor was found on her left ovary and she received a diagnosis of ovarian cancer. For her, this diagnosis felt out of left field. She felt alone and scared, but knew the importance of having the right information to make treatment decisions.
Genetic testing revealed Leanne did not have the BRCA mutation. Like Leanne, approximately 80% of all ovarian cancer patients do not have a BRCA mutation.5 What both Cherie and Leanne would find out, is that though they have different genetic dispositions and biomarkers, they would be able to start on a treatment that would provide them a sense of control as they navigated advanced ovarian cancer.
Treatment and potential recurrence
Cherie began treatment with debulking surgery, the surgical removal of as much of a tumor as possible,6 followed by chemotherapy. She knew that her cancer was likely to come back even if she had a positive response to chemotherapy and she wanted to be as proactive as possible to delay the time before a potential recurrence.
Cherie was thankful her doctor suggested maintenance therapy as an option early on.
Following Leanne’s diagnosis, she underwent multiple cycles of chemotherapy. Leanne and her gynecologic oncologist discussed maintenance treatment options that she would be eligible for as a woman who does not have the BRCA mutation.
Maintenance therapy is a treatment given to eligible patients, who have a complete or partial response to chemotherapy, which may delay the time before the cancer progresses. As a result of these proactive conversations with their doctors and after carefully considering their options, Leanne and Cherie started ZEJULA (niraparib, 100mg capsules). ZEJULA is an oral medicine known as a PARP-inhibitor, which works by preventing cells from repairing their damaged DNA in both healthy cells and cancer cells.
ZEJULA is a prescription medicine used for the maintenance treatment of adults with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. ZEJULA is used after the cancer has responded (complete or partial response) to treatment with platinum-based chemotherapy.
It is not known if ZEJULA is safe and effective in children.
ZEJULA may cause serious side effects such as bone marrow problems called myelodysplastic syndrome (MDS) or a type of blood cancer called acute myeloid leukemia (AML), which may lead to death. Symptoms of low blood cell counts may include weakness and can be a sign of serious bone marrow problems. Contact your doctor for new onset of bleeding, fever, or infection. High blood pressure is common and can become serious. Posterior Reversible Encephalopathy Syndrome (PRES) is a condition that affects the brain and may happen during treatment with ZEJULA. Tell your doctor if you have headache, vision changes, confusion, or seizure. Tell your doctor about all your medical conditions and medications, and if you are pregnant or breastfeeding or plan to be. Some common side effects include nausea, low blood cell counts, tiredness, constipation, muscle and back pain, headache, and trouble sleeping.
Please see additional Important Safety Information below and full Prescribing Information.
Cherie’s and Leanne’s experience demonstrated how critical it is to educate women with advanced ovarian cancer on the benefits and risks of maintenance treatment options, like ZEJULA. Cherie and Leanne continue to keep an open communication with their doctors, scheduling regular visits as part of routine monitoring required with ZEJULA as well as to monitor for an ovarian cancer recurrence. The reality is, nearly 85% of women with advanced ovarian cancer will see the cancer return after treatment.7 By learning about maintenance therapies and discussing their options with healthcare teams as early on as possible, it may help them regain a sense of control over their disease.
Cherie, who is BRCA-positive, and Leanne, who is BRCA-negative, were grateful that ZEJULA is a maintenance treatment option for all eligible women after response to platinum-based chemotherapy, regardless of biomarker status, including those who may have another genetic factor based on their tumor, known as homologous recombination deficiency (HRD). Homologous recombination is a process by which DNA is repaired, so when the body is unable to repair double strand breaks in DNA, it is known as homologous recombination deficiency. If a tumor tests positive for HRD, it means that the cancer cells will have a harder time repairing themselves, and that the tumor itself may be sensitive to certain treatments8, such as ZEJULA. Testing for HRD is done after diagnosis, on the tumor itself.
ZEJULA is a maintenance therapy option for those with HRD-positive tumors, who make up about 50% of women with ovarian cancer9. In sharing their stories, Leanne and Cherie hope to spread the word so other women with ovarian cancer feel empowered to know their options and make informed decisions about their treatment plan with their healthcare team. Talk to your doctor about ZEJULA and visit zejula.com for more information.
Advice for other women
"I wish I knew that cancer doesn’t wait for you to be ready," says Cherie. "Despite how I got here, I wish I knew it wasn’t my fault, that I’m stronger than I know, and that no matter what happens it will all work out."
Her advice to others: "Seek support through organizations or ovarian cancer online support groups. Communicate with your doctors. Do not be afraid to seek mental health help through a psychologist. Try to be as active as possible. Don’t be afraid to ask for help."
Leanne also recommends, "Take someone with you to initial treatments and appointments to take notes and help clarify things. So much information is coming at you and you are still processing everything. Continue to take the notebook to appointments and treatments as well as making notes when you’re at home. It helps you remember what to discuss with your doctor."
Indication and Important Safety Information
Important Safety Information
ZEJULA may cause serious side effects, including:
Bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of blood cancer called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during treatment with ZEJULA. MDS or AML may lead to death.
Symptoms of low blood cell counts (low red blood cells, low white blood cells, and low platelets) are common during treatment with ZEJULA. They can be a sign of serious bone marrow problems, including MDS or AML. These symptoms may include the following:
Your doctor will do blood tests to check your blood cell counts before treatment with ZEJULA. You will be tested weekly for the first month of treatment with ZEJULA, monthly for the next 11 months of treatment, and from time to time afterward.
High blood pressure is common during treatment with ZEJULA, and it can become serious. Your doctor will check your blood pressure and heart rate at least weekly for the first two months, then monthly for the first year, and as needed thereafter during your treatment with ZEJULA.
Posterior reversible encephalopathy syndrome (PRES) is a condition that affects the brain and may happen during treatment with ZEJULA. If you have headache, vision changes, confusion, or seizure, with or without high blood pressure, please contact your doctor.
Before starting to take ZEJULA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of ZEJULA include the following:
If you have certain side effects, then your doctor may change your dose of ZEJULA, temporarily stop, or permanently stop treatment with ZEJULA.
These are not all the possible side effects of ZEJULA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see Prescribing Information.
©2021 GSK or licensor.
NRPOGM210104 September 2021
Produced in USA.
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